| Diabetes/Metabolism Research and Reviews,19:386-391, 2003 |
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| The appearance of aggregated erythrocytes in the peripheral blood
of individuals with insulin resistance |
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| D Justo, R. Marilus, T. Mardi, T. Tolchinsky, Y. Goldin, M. Rozenblat,
O. Rogowski, Y. Yerushalmi, N. Stern, G. Shenkerman, V. Deutsch, D.
Zeltser, |
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| TEL AVIV SOURASKY MEDICAL CENTER |
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| BACKGROUND: Insulin resistance is associated with low-grade inflammatory
response. The probability that the acute-phase response is associated
with enhanced erythrocyte adhesiveness/aggregation was not explored.
METHODS: The degree of erythrocyte adhesiveness/aggregation was evaluated
by using a simple slide test. The insulin resistance was evaluated
by insulin and glucose concentrations after a night of fasting. The
inflammatory response was evaluated by variables of acute-phase response.
RESULTS: A significant correlation (r = -0.2, p = 0.02) was noted between
insulin resistance expressed as the HOMA index and the degree of erythrocyte
adhesiveness/aggregation. This was probably due to the concomitant
acute-phase response and the presence of increased amounts of inflammation-sensitive
proteins that were found to correlate significantly with the degree
of erythrocyte adhesiveness/aggregation. In the multiple linear regression
analysis, erythrocyte sedimentation rate and fibrinogen concentration
but not HOMA index were found to correlate significantly (p < 0.0001
and p = 0.0007 respectively) with the degree of red blood cell adhesiveness/aggregation.
CONCLUSIONS: Insulin resistance is associated with an enhanced degree
of erythrocyte adhesiveness/aggregation and this is related to the
presence of enhanced inflammation-sensitive plasma proteins that are
part of the acute-phase response. These findings might have hemorheological
consequences and might contribute to the pathophysiology of the insulin-resistance
syndrome. |
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