מאמרים כחול-לבן
| Am.. J. Hypertens. Vol 16(9): 715-8, 2003. |
| Treatment with Amlodipine and Atorvastatin have additive effect in improvement of arterial compliance in hypertensive hyperlipidemic patients. |
| Leibovitz E, Beniashvili M, Zimlichman R, Freiman A, Shargorodsky M, Gavish D. |
| From the Department of Medicine and the Bruner Institute of Cardiovascular Research, Wolfson Medical Center, Holon, and the Sackler Faculty of Medicine Tel Aviv University, Tel Aviv |
| Background: This study investigates the effect of amlodipine on arterial
compliance (AC), and the effect of atorvastatin on AC when given in
combination with amlodipine. Methods: Twenty-one consecutive hypertensive hyperlipidemic patients were included in this study. Patients were followed every month for 6 months (3 months of amlodipine therapy and 3 months of amlodipine and atorvastatin combination). Results: During the 3 months of amlodipine monotherapy, large and small AC were improved by 26% and 38%, respectively, and the systemic vascular resistance was reduced by 10%. The addition of atorvastatin during the next 3 months improved small AC by an additional 42% and decreased the systemic vascular resistance by another 5%, but large AC and blood pressure did not change. Conclusions: Amlodipine improves large and small AC, and the beneficial effect of atorvastatin on small AC is additive to the effect achieved by amlodipine. |