| Int J Obes Relat Metab Disord. 2004 Dec;28:1528-34 |
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| Flow-resistant red blood cell aggregation in morbid obesity |
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| Samocha-Bonet D, Ben-Ami R, Shapira I, Shenkerman G, Abu-Abeid S,
Stern N, Mardi T, Tulchinski T, Deutsch V, Yedgar S, Barshtein G, Berliner
S. |
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| Department of Internal Medicine D, Tel Aviv Sourasky Medical Center,
Tel Aviv, Israel. |
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| OBJECTIVE: Enhanced red blood cell (RBC) aggregation has an adverse
effect on microcirculatory blood flow and tissue OXYGENation.
It has been previously shown that obesity is associated with increased
RBC aggregation. The objectives of the present study were to further
characterize obesity-related RBC aggregation and to examine whether
the enhanced aggregation is a plasma- or cellular-dependent process.
METHODS: Obese (body mass index (BMI)=40+/-6.3 kg/m2, n=22) and nonobese
(BMI=24+/-3.4 kg/m2, n=18) individuals were evaluated for inflammation
markers and aggregation parameters. Aggregation parameters were derived
from the distribution of RBC population into aggregate sizes, and from
the variation of the distribution as a function of flow-derived shear
stress, using a cell flow properties analyzer. To differentiate plasmatic
from cellular factors, we determined the aggregation in the presence
of autologous plasma or dextran-500 kDa and calculated the plasma factor
(PF) in the obese group. PF ranges from 0 to 1. When the PF=1, the
aggregation is all due to plasmatic factors, when PF=0, the altered
aggregation depends entirely on cellular factors, whereas 0 |
