| IMAJ 2005;(Dec)7:812-5,2005 |
|
| Intravenous Chlorpromazine for the Emergency Treatment of uncontrolled
symptomatic hypertension in the Pre–Hospital Setup. Data from almost
500 consecutive cases |
|
| Viskin S, Berger M, Ish-Shalom M, Malov N, Tamari M, Golovner M,
Kehati M, Zeltser, D, Roth A |
|
| Departments of Cardiology, Internal Medicine
D & T Tel-Aviv Sourasky
Medical Center and ′SHL′ Medical Services, Israel |
|
| Background. CHLORPROMAZINE is
a DOPAMINE-receptor
antagonist antipsychotic agent. Because of its strong alpha-blocking
and sedative actions, CHLORPROMAZINE has
also been used as emergency therapy of extreme arterial hypertension.
Published reports, however, have included very small numbers of patients
(from 5 to 30 patients). Methods. We reviewed data from 496 consecutive
patients who received intravenous CHLORPROMAZINE as
emergency therapy for uncontrolled symptomatic hypertension. CHLORPROMAZINE was
injected intravenously. The dose was 1 mg every 2-5 minutes until the
systolic pressure was ≤140 mmHg and the diastolic pressure was ≤100
mmHg with alleviation of symptoms. Results. The mean dose of CHLORPROMAZINE administered
was 4.5 ± 5 mg (range 1 – 50 mg). Only 33 patients (7%) patients required
more than 10 mg. CHLORPROMAZINE reduced
the systolic blood pressure from 222.82 ± 26.31 to 164.93± 22.66 mmHg
(p<0.001) and the diastolic blood pressure from 113.5 ± 16.63 to
85.83 ± 11.61 mmHg, (p<0.001). Sinus rate decreased from 97.9 ±
23.5 to 92.2 ± 19.7 beats per min (p<0.001). These results were
achieved within the 37 ± 11 minutes. Conclusions. Intravenous CHLORPROMAZINE is
safe and effective when used as emergency therapy of uncontrolled symptomatic
hypertension. |
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